Glutaric Aciduria I

Photo by Dr. Goodman

History: Glutaric Aciduria Type I (GA I) was first described by Distinguished Professor Stephen Goodman in 1975. The Goodman laboratory, including Dr. Woontner, focused on GA I for over forty years. We are honored to continue this work at the University of Colorado.

Research: We are focused on the role of lysine metabolism, specifically the metabolites glutaric acid and 3-hydroxy-glutaric acid, in the development of striatal necrosis. Current treatments include reducing oral lysine intake and limiting catabolism with the goal of reducing the accumulation of 3-hydroxy-glutraic acid. Using zebrafish as a principal model, we aim to investigate the role of metabolism in disease pathophysiology and evaluate novel treatments for this neurologic disorder.

Curtis R. Coughlin II
Curtis R. Coughlin II
Associate Professor

My research interests include inborn errors of metabolism that impact neurologic function with a focus on pyridoxine-dependent epilepsy, glutaric aciduria I, and vitamin B6 metabolism.